Rather than rebuilding the conserved axonemal ‘9 + 2’ structure, SKAP2 appears to enhance sperm motility and morphology by promoting proper flagellar bending, stabilizing acrosome adhesion, and optimizing mitochondrial organization, thereby uncovering a novel mechanistic insight into the therapeutic potential of mEVs-SKAP2 on male infertility. Here, SKAP2 is linked to male infertility.