CASP1 and systemic lupus erythematosus: Carbobenzoxy-valyl-alanyl-aspartyl-(β-o-methyl)-fluoromethylketone (ZVAD-fmk) is a pancaspase inhibitor that inhibits a broad spectrum of caspases, in particular caspase-1, caspase-3 and caspase-11 with high affinity in the murine model.24, 28 It ameliorates renal disease in IFN-γ-transgenic lupus models by reducing apoptosis-mediated nucleosome release and immune complex deposition.29