CASP1 and lupus nephritis: While caspase-1 inhibition by genetic deletion in inducible lupus models has already been shown to protect against autoantibody formation, type I interferon responses, vascular dysfunction and immune complex glomerulonephritis,32 we demonstrate in our work that selective pharmacologic caspase-1 inhibition is effective in a spontaneous lupus model, ameliorating systemic disease and lupus nephritis.