Both society guidelines agree on thefollowing classes for migraine prevention: calcitonin gene-related peptides(CGRP) receptor antagonists or antibodies, OnabotulinumtoxinA (Botox),beta-blockers, Angiotensin-Converting Enzyme (ACE) inhibitors, andanti-epileptics [7, 8]. The gene discussed is ACE; the disease is migraine disorder.