Furthermore, reduced functioning of histone deacetylaseinhibitors such as Sirtuin protein (SIRT1) in the central amygdala has beenreported to be associated with the development of comorbid anxiety and depressionand changes in orofacial sensorimotor behaviors in a trigeminal neuropathic painmodel; the SIRT1 changes represent an epigenetic mechanism underlying individualpain vulnerabilities to emotional disorders [113]. The gene discussed is SIRT1; the disease is Anxiety.