MAPT and Alzheimer disease: In DLB patients with iRBD at baseline, neuroimaging studies showed a lower burden of phospho-tau and Aβ in both hippocampus and amygdala, compared to those without iRBD, who instead showed a greater atrophy in temporoparietal cortices, hippocampus and amygdala; concluding that having RBD at baseline was associated with a higher likelihood of developing DLB as an overt stage of α-synucleinopathy, and showing a less severe AD-related pathology [31].