They report that APOE ε4 was associated with DLB patients with both intermediate and high AD co-pathology, but not with pure DLB cases, concluding that APOE ε4 does not represent an independent driver of a-synuclein pathology but, on the other hand, its association with DLB is dependent on the severity of AD co-pathology [25]. The gene discussed is APOE; the disease is Lewy body dementia.