This SNP causes a synonymous change in MT‐ND5, but is a variant (rs2853499) encoding a non‐synonymous D47N mutation in the microprotein SHMOOSE that has been associated with an increased risk of Alzheimer's Disease and increased brain atrophy of medial temporal regions in European subjects (Miller et al. 2023). This evidence concerns the gene MT-ND5 and early-onset autosomal dominant Alzheimer disease.