These findings could serve as a foundation for developing targeted therapeutic strategies to address the detrimental consequences of Ndel1 deficiency, which was reported in diverse pathological conditions, including neurodevelopmental pathologies such as microcephaly, macrocephaly, among others, as well as in mental disorders, such as SZ, BD, FEP, ASD, among others. Here, NDEL1 is linked to Macrocephaly.