The NudE neurodevelopment protein 1 like 1 (Ndel1) oligopeptidase is an enzyme with potential as a biomarker for supporting the diagnosis of schizophrenia (SZ) (Gadelha et al. 2013) and other mental disorders including bipolar disorder (BD) (Dal Mas, Carvalho, et al. 2019), as well as proven to be useful for monitoring the responses to pharmacotherapy in early‐stage SZ (Dal Mas, Nani, et al. 2019; Nani et al. 2024) and in reversion of zika virus induced microcephaly (Christoff et al. 2023). Here, NDEL1 is linked to mental disorder.