More recently, a growing interest in Ndel1's potential as a neurodevelopmental biomarker was motivated by the demonstration of the association of this oligopeptidase activity with aberrant neurodevelopment pathologies, such as in idiopathic autism spectrum disorder (ASD) showing macrocephaly associated with severe clinical symptoms (Nani, Fonseca, et al. 2020; Courchesne et al. 2024). The gene discussed is NDEL1; the disease is Macrocephaly.