Therefore, to determine whether hNSC‐ and iMGL‐derived EVs exert an effect on synaptic integrity in the 5xFAD mouse, we evaluated the immunoreactivity of the postsynaptic marker synaptophysin (Syn) in the mPFC and PRh cortical regions of WT control mice and AD mice treated with vehicle, hNSC‐, or iMGL‐EVs. The gene discussed is SYP; the disease is Alzheimer disease.