BDNF and Alzheimer disease: Several AD studies using NSC transplantation in mouse models demonstrated improvements in cognition correlated with improved normal homeostasis via neuroprotective strategies including reduction in proinflammatory glial responses (Lee et al. 2015), improved neuronal metabolic activity (Li et al. 2016), and increased levels of brain derived neurotrophic factor (BDNF) (Blurton‐Jones et al. 2009).