The 10-protein LFC score, comprising proteins involved in adipogenesis, lipid metabolism, and insulin signaling (IGFBP2, FABP4, MET, CPM, CES1, IGFBP1, CDHR2, RBP5, ERBB2, SSC5D), showed superior diagnostic accuracy for hepatic steatosis compared to fatty liver index(FLI) (AUC = 0.850 vs. 0.794). Here, IGFBP2 is linked to Hepatic steatosis.