scRNA-seq and scTCR-seq analysis show that cKO mice exhibit reduced immunosuppressive Ms4a7<sup>+</sup>C1qa<sup>+</sup> tumor-associated macrophages (TAMs) but increased intratumoral IFN-γ<sup>+</sup>CD8<sup>+</sup> T cell infiltration and expansion. The gene discussed is CD8A; the disease is neoplasm.