Among 4680 (hsCRP) and 4580 (IL-6) participants (median follow-up for incident CKD: 16.8 years), higher IL-6 was consistently associated with faster eGFR decline [tertile 3 (T3; vs. T1): -0.32 mL/min/1.73m2/year (95% CI: 0.23-0.42 mL/min/1.73m2/year), P < 0.001] greater log[UACR] increase [T3: 6.67 × 10-3 unit/year (2.95 × 10-3-10.39 × 10-3 unit/year), P < 0.001], and higher CKD incidence [T3: sub-hazard ratio 1.65 (1.23-2.20), P = 0.001]. The gene discussed is IL6; the disease is chronic kidney disease.