CYP4Z1 and breast cancer: CYP4Z1 and CYP4Z2P compete with a number of tumor-suppressive miRNAs, including miR-211, miR-125a-3p, miR-197, miR-1226, and miR-204, to create a ceRNA network known as ceRNET_CC.136, 137, 138, 139, 140 ceRNET_CC suppresses apoptosis and induces angiogenesis and tamoxifen resistance.141, 142, 143 Zheng et al reported that breast cancer tissues had higher expression levels of transcriptional factor SIX homeobox 2 (six 2), CYP4Z1, and CYP4Z2P.105