TPTEP1 and central nervous system cancer: ,153 Altogether, TPTEP1 acted as a tumor suppressor by interacting with miR-106a-5p to create a reciprocal regulatory network that promoted the activation of P38 MAPK signaling in gliomas149; so TPTEP1 can be targeted to treat glioma and has the potential to become both a diagnostic and prognostic factor.