Ali et al 54 used T cell phenotyping in 72 ADPKD patients and revealed significantly raised CD3+ T cells, CD4+, CD8+, double-negative, and double-positive subsets, as well as significantly elevated IFN- and TNF-producing subsets of CD4+/CD8+ cells. The gene discussed is CD8A; the disease is autosomal dominant polycystic kidney disease.