Alternatively, activated macrophages promote renal fibrosis by producing profibrotic factors, Gal-3,118 insulin-like growth factor-1 (IGF-1),119 TGF-β1,120 and platelet-derived growth factor (PDGF),121 which promote myofibroblast proliferation and survival. The gene discussed is IGF1; the disease is renal fibrosis.