CRP and major depressive disorder: A more recent mega-analysis of data from the Psychiatric Genomics Consortium (PGC) showed that patients with MDD endorsing atypical features, relative to their non-atypical MDD counterparts, carried a higher load of genetic variants associated with immune-metabolic dysfunction such as elevated body-mass index and higher blood levels of C-reactive protein—CRP, a broad marker of pro-inflammatory signaling (Milaneschi et al., 2017).