Moreover, this case proves that a three-missense pathogenic variant in the CYP21A2 gene as p.[Ile237Lys;Val238Glu;Met240Lys], brings about an SW form of 21-OHD. We think that the information, including genomic, in this case report would be useful for evaluating 21-OHD in the future. This evidence concerns the gene CYP21A2 and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.