The results of our case also show and remind us once again that three-missense pathogenic variants in the CYP21A2 gene of p.[Ile237Asn or Lys; Val238Glu; Met239Lys or Met240Lys] are important lesions of the enzyme activity of 21‐hydroxylase and cause the onset of 21-OHD. This evidence concerns the gene CYP21A2 and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.