The search strategy used the following combination of terms: (“hypertension” OR “high blood pressure”) AND (“osteoporosis” OR“bone loss”), supplemented with pharmacologic terms including “ACE inhibitors”, “Angiotensin receptor blockers”, “Thiazide diuretics”, “Beta Blockers”, “SERMS”, “Bisphosphonates”, “Denosumab”, “romosozumab”, and “teriparatide”. The gene discussed is ACE; the disease is Hypertension.