LDL-C: low-density lipoprotein cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; sd-LDL: small dense low-density lipoprotein; ASCVD: atherosclerotic cardiovascular disease; CV: cardiovascular; EPA: eicosapentaenoic acid; DHA: docosahexaenoic acid; HF: heart failure; MACE: major adverse cardiovascular events; ANGPTL3: angiopoietin-like 3; REDUCE-IT: Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial. Here, ANGPTL3 is linked to heart failure.