The preclinical models of middle cerebral artery occlusion (MCAO) and stroke-prone spontaneously hypertensive rats (SHR/SP) demonstrate how MetS causes neuroglial inflammation through the activation of thioredoxin-interacting protein (TXNIP) and NOD-like receptor protein 3 (NLRP3) inflammasome which results in hippocampal and prefrontal cortical neuronal dysfunction [69]. This evidence concerns the gene TXNIP and stroke disorder.