PRSS2 and alkaline phosphatase measurement: The Cochrane review carried out research that summarized the results of 10 studies (with more than 5,000 participants) and found that serum amylase, serum lipase, and urinary trypsinogen-2 exhibited the same sensitivity (0.72-0.79) and specificity (0.89-0.93), but still about a quarter of patients with AP were not diagnosed by these measurements.