DNMT3A and cyclic hematopoiesis: Notably, CH-associated mutations are predominantly observed in circulating granulocytes, monocytes, and natural killer cells, but are rarely present in B cells and infrequently detected in T cells.[32] DNMT3A mutations have been reported in the T cells of 30% to 50% of individuals with DNMT3A-mutated clonal hematopoiesis of indeterminate potential.[32,33] One possible explanation is that these mutations may alter hematopoietic stem cell differentiation away from the T-cell lineage or occur in progenitor cells that have already lost the potential to differentiate into T cells.