VEGFA and colorectal carcinoma: The up-regulation of LDH ensures efficient energy utilization by tumor cells, and the resulting acidic environment also further promotes tumor proliferation and invasion.[37–39] In addition, LDH 5 was also found to be closely related to the activation of vascular endothelial growth factor pathway, thereby promoting tumor vascular proliferation.[40] In CRC, elevated serum LDH level was associated with poor OS.[41–43]