ALB and liver disorder: ALP is mainly derived from the liver and bone, and its elevated serum level is often associated with liver diseases, such as hepatitis, cirrhosis, and liver tumors.[18] It has recently been suggested that increased ALP levels might also be associated with CRC progression and poor prognosis.[19,20] Notably, considering the role of serum albumin (ALB) and bilirubin in reflecting liver function, the albumin-bilirubin (ALBI) score, initially used to assess liver function,[21] has also been reported as an independent risk factor for CRC patients undergoing radical resection.[22,23]