Therefore, it is necessary to combine new factors to assist in judging the prognosis of CRC.[28] In recent years, more and more blood biomarkers have been found to be associated with the prognosis of CRC, based on which prognostic models have been established, such as tumor markers CEA and CA19-9,[29–32] inflammation-related markers,[33] etc. Liver function-related blood markers, including ALB, LDH, ALP, and GGT,[17,19] have been confirmed to be associated with the prognosis of CRC by other studies, but their predictive value is still unclear. This evidence concerns the gene ALB and colorectal carcinoma.