CACNA1A and epilepsy: The findings of this study do not support a direct causal link between migraine and epilepsy, seemingly contradicting previous research that identified shared genetic mutations in genes such as CACNA1A, ATP1A2, and SCN1A implicated in both conditions.[48] This genetic overlap suggests a predisposition for coexistence rather than causal interaction.[49] For instance, a large-scale GWAS identified 3 susceptibility genes for MO, with LRP1 being a lipoprotein associated with glutamate receptors.[50] Although glutamate has excitatory properties, it appears unrelated to epilepsy.