Tumor-associated macrophages (TAMs) are important inflammatory cells in the tumor microenvironment.[25] TAMs consist of 2 subtypes: M1 and M2.[26] M1-subtype TAMs, known as classically activated macrophages, demonstrate pro-inflammatory and anti-tumor properties, while M2-subtype TAMs, known as alternatively activated macrophages, facilitate tumor growth, angiogenesis, and suppress adaptive immunity.[27] CD68+ and CD163+ are widely used biomarkers for detecting TAMs in tumor specimens. The gene discussed is CD68; the disease is neoplasm.