TR B cell %lymphocyte, CD25 on IgD− CD24− B cell, and HLA DR on CD14− CD16+ monocyte are risk factors for the onset of rosacea, while central memory CD4− CD8− T cell AC, CCR7 on naive CD4+ T cell, CD14+ CD16− monocyte AC, and CD62L − mDC are protective factors for the onset of rosacea. This evidence concerns the gene CD4 and rosacea.