The CD14− CD16+ phenotype predominantly identifies monocytes, which are crucial for signal recognition and transduction.[33,34] A retrospective study demonstrated that the monocyte count in the blood of patients with rosacea was significantly higher than that of healthy controls.[35] Another study observed an increased proportion of classical monocytes in the peripheral blood of patients with rosacea, while the proportions of intermediate and nonclassical monocytes remained unchanged. Here, CD14 is linked to rosacea.