Our research findings revealed that CXCL11 levels (OR = 1.265, 95% CI = 0.985–1.625) and T-cell surface glycoprotein CD6 isoform levels (OR = 1.372, 95% CI = 1.069–1.761) show a positive correlation with the risk of rosacea, while monocyte chemoattractant protein-1 (MCP-1) levels (OR = 0.772, 95% CI = 0.621–0. This evidence concerns the gene CXCL11 and rosacea.