Notably, the MICA-129 Val/Val genotype was identified as a risk genotype and a poor prognostic biomarker in the Tunisian population.[15] This discrepancy suggests that the association between MICA-129 and CRC susceptibility varies across populations and is affected by differing haplotype structures, regional environmental factors, or interactions with other unidentified genetic variants. The gene discussed is MICA; the disease is colorectal carcinoma.