Owing to its potential to impact MICA biology, the MICA-129 dimorphism has raised substantial research interest.[15–19] The MICA alleles are classified as either strong (MICA-129Met) or weak (MICA-129Val) binders to the NKG2D receptor because of a substitution of methionine (Met) for valine (Val) at codon 129 of the α2 heavy chain domain.[20] The MICA-129 Val/Val variant is associated with significantly higher sMICA levels[21] and the progression of multiple myeloma. The gene discussed is MICA; the disease is plasma cell myeloma.