sMICA, combined with the patient’s MICA genotype, can serve as a definitive prognostic indicator of multiple myeloma.[22] Similarly, the MICA-129 Val allele influences individual susceptibility for breast cancer development in Tunisian women.[23] However, the association between MICA-129 polymorphism and CRC in the Chinese population remains unexplored. The gene discussed is MICA; the disease is colorectal carcinoma.