To further evaluate the association between the MICA-129 polymorphism and CRC diagnostic biomarkers, the dependent linkage between the MICA-129 polymorphism and carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), and CYFRA21-1 (serum biomarkers) was investigated. This evidence concerns the gene CEACAM5 and colorectal carcinoma.