Specific MICA-129 single nucleotide polymorphism was analyzed for its association with CRC susceptibility, clinical phenotypes, and selected CRC-associated microsatellite instability, driver gene mutation, immune checkpoint programmed death ligand 1, and diagnostic biomarkers carbohydrate antigen 19-9 and carcinoembryonic antigen. The gene discussed is CEACAM5; the disease is colorectal carcinoma.