SMARCA1 and cancer: SMARCA4 is a member of SWI/SNF chromatin remodeling complex, which has anti-cancer function.[9] SMARCA4 mutations are detected in > 90% of SCCOHT cases, as compared with 0.4% of other primary ovarian tumors.[10] In this case, SMARCA4 gene mutation was detected as a frameshift mutation, resulting in loss of protein function, which further confirmed the pathological diagnosis.