SLC26A6 and chronic hepatitis B virus infection: ADV is a commonly used antiviral agent for the treatment of chronic hepatitis B. While renal toxicity typically occurs at doses of 30 mg/d, it can also occur at lower doses, such as 10 mg/d, with dose- and time-dependent effects.[4–6] The mechanism of ADV-induced renal toxicity involves binding to anion transporter-1 in the renal tubule epithelium, where it inhibits mitochondrial DNA polymerase.