At the 2018 International Consensus Meeting, serum CRP, serum ESR, and elevated serum D-dimer were defined as secondary criteria in the revised International Consensus Meeting criteria.[20] To improve the accuracy of diagnosing periprosthetic infections, combining ESR and serum CRP levels is recommended.[21] The detection of elevated CRP and ESR levels can diagnose postoperative infection after TKA. This evidence concerns the gene ESR1 and infection.