It has been discovered that DM slows down wound healing, increases the resorption of alveolar bone, and has been implicated in the compromised outcome of replacing teeth.[33,34] DM is a disease resulting from impaired insulin availability in the body, leading to increased blood glucose which is called as (type 1 DM), or varying degree of insulin resistance or unable to use the available insulin by the body, which is called (type 2 DM). The gene discussed is INS; the disease is Insulin resistance.