LCN2 and lung carcinoma: LCN2 serves as a mediator in numerous diseases related to cachexia, inducing ferroptosis and depletion of adipose and muscle tissues in lung cancer cachexia.[52] The knockdown of iron metabolism genes FPN and LCN2 via CRISPR/Cas13a and microRNA gave rise to significant ferroptosis in multiple hematological and solid tumor cancer cells.[53]