Subsequently, the analysis of the expression of these genes in PAADs indicated that there were substantial differences in the expression of CHGA, CHGB, PCSK2, PCSK1N, DLGAP1 and DLGAP3 genes in PAAD with and without lymphatic metastasis, and their expressions were down-regulated in the lymphatic metastasis group (Fig. 4). The gene discussed is DLGAP3; the disease is pancreatic adenocarcinoma.