NFE2L2 and cancer: Conversely, inhibiting the activity of BCAT2 triggers ferroptosis in cancer cells.[49] Microsomal glutathione S-transferase 1 (MGST1), a selenium-independent glutathione peroxidase, plays a crucial role in safeguarding the endoplasmic reticulum and the outer membrane of mitochondria from lipid peroxidation, thereby protecting cells from ferroptosis.[50] The deletion of the MGST1 gene facilitates ferroptosis in pancreatic cancer cells, and the reexpression of MGST1 restores the resistance of NFE2L2 knockdown cells to ferroptosis.