Chromogranin A has been proposed as promising biomarkers for Colorectal Cancer detection in the early stages.[22] CHGB is one of the 2 major soluble proteins in the chromophobe granules of the adrenal medulla.[23] CHGB, instrumental in immune modulation, exhibits deviant gene expression across myriad tumor varieties, with its augmented expression being intrinsically linked to metastatic events. The gene discussed is CHGA; the disease is colorectal cancer.