Chromogranin A has been proposed as promising biomarkers for Colorectal Cancer detection in the early stages.[22] CHGB is one of the 2 major soluble proteins in the chromophobe granules of the adrenal medulla.[23] CHGB, instrumental in immune modulation, exhibits deviant gene expression across myriad tumor varieties, with its augmented expression being intrinsically linked to metastatic events. This evidence concerns the gene CHGB and colorectal cancer.