Subsequent research has explored circRNA expression patterns in relation to PD prognosis and diagnosis using blood samples and postmortem tissues, leading to the identification of several potential biomarkers.[9,25,26] A recent study by Cheng Q et al reported dysregulation of circSV2b in a PD mouse model.[27] Mechanistic analysis revealed that circSV2b interacts with the miR-5107-5p–Foxk1–Akt1 axis, thereby regulating oxidative stress in PD. This evidence concerns the gene AKT1 and Parkinson disease.