SNCA and Parkinson disease: In addition to miR-7 and miR-153, studies have shown that long intergenic noncoding RNA-p21 upregulates α-synuclein expression by sponging miR-1277-5p in PD, ultimately promoting cell apoptosis.[15] Regarding other ncRNA types, further evidence indicates that the circSNCA-miR-7-α-synuclein network positively regulates α-synuclein levels and induces apoptosis, suggesting that ncRNAs may serve as potential novel therapeutic targets for PD.[10]