ENO2 and nervous system disorder: Neuron-specific enolase (NSE) serves as a glycolytic enzyme that is specifically found in neurons and certain neuroendocrine cells.[6] Increased concentrations of NSE in the serum have been observed in a range of neurological disorders, such as brain injuries caused by trauma, stroke, and diseases associated with neurodegeneration, where it serves as a marker of neuronal damage.[7] Whether it similarly reflects acute injury in children with febrile convulsions remains unclear—although some studies have suggested a possible association.[8]