The missense variant p.Glu197Lys of SCNN1G, which encodes for the amiloride-sensitive epithelial Na+-channel ENaCγ, was previously identified in 2 patients with severe bronchiectasis.[20] Defective SCNN1G variants are known to lead to impaired alveolar and lung function,[29] which could hypothetically cause hypoxia and SE. The gene discussed is SCNN1G; the disease is bronchiectasis.