Its expression is suppressed by isoginkgetin through CDK6 degradation and inhibition of the AMPK-ULK1 pathway,[36] and is also regulated by lncRNA FTO-IT1[37] and SLC2A1-DT[38] via m6A RNA modification or positive transcriptional regulation by c-Myc, thereby enhancing glucose uptake, glycolysis, and autophagy, ultimately driving HCC progression. This evidence concerns the gene CDK6 and hepatocellular carcinoma.