COG2 and chronic kidney disease: Numerous epidemiological studies have identified elevated LDL-C, particularly ApoB, which reflects the number of atherogenic lipoprotein particles, as an independent risk factor for the occurrence, progression, and cardiovascular complications of CKD.[81] These studies generally indicate that increased levels of LDL-C and ApoB are significantly associated with an accelerated decline in the estimated glomerular filtration rate (eGFR) and the occurrence and exacerbation of proteinuria, such as elevated albuminuria.