ADRB1 and central nervous system cancer: Stigmasterol, (S)-stylopine, isobrucine, icaride A, and isostrychnine N-oxide (I), which may act on key targets such as ADRB1, ADRB2, CHRM3, ADRA1A, and ESR1, are the main ingredients of semen strychni used to treat gliomas.