Stigmasterol, (S)-stylopine, isobrucine, icaride A, and isostrychnine N-oxide (I), which may act on key targets such as ADRB1, ADRB2, CHRM3, ADRA1A, and ESR1, are the main ingredients of semen strychni used to treat gliomas. Here, CHRM3 is linked to glioma.