For example, asthma and challenging behaviour in CDKN1C, triangular facies, cleft palate, ectrodactyly, presence of pigmented nevi, high-pitched voice and male genital abnormalities in IGF2, microcephaly in HMGA2, and microcephaly, learning difficulties and thin hair in PLAG1. Congenital cardiac disorders were largely restricted to 11p15LOM and IGF2 variants. This evidence concerns the gene PLAG1 and asthma.