For the SNP rs4942254 (CCDC122-LACC1), it was possible to identify in the CC genotype a statistically significant association with a lower risk of leprosy in the population of Alagoas (ORCC = 0.56, 95% CI = 0.34–0.92, p = 0.02), and in the combined analysis of the populations (ORCC = 0.65, 95% CI = 0.45–0.94, p = 0.03). The gene discussed is LACC1; the disease is leprosy.