The administration of the vaginal metabolite 5-formamidoimidazole-4-carboxamide ribotide to HGSOC cells and xenografted tumor models in nude mice resulted in the inhibition of cell proliferation and tumor growth of HGSOC, which was achieved by the inhibition of the METTL1/BRCA1 axis. The gene discussed is BRCA1; the disease is neoplasm.