Alzheimer’s disease (AD), which affects approximately 50 million people worldwide, is characterized by the accumulation of neurotoxic amyloid-β (Aβ) peptides—derived from amyloid precursor protein (APP)—and the formation of neurofibrillary tangles in the brain, resulting in cognitive decline and brain atrophy5. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.