KLK3 and Cowden syndrome 1: On the multivariate level, only nadir PSA (< vs. > 30 ng/ml) in castration sensitive setting was statistically significant for PFS (p = 0.002) while the type of first-line therapy in castration resistant setting (ARPI vs. Docetaxel), duration of therapy in CS setting (≤ vs. ≥ 12 months) and the presence of visceral metastasis were all significant factors for OS (p = 0.043, 0.017 and 0.03 respectively).