TP53 and neoplasm: From a feature complementarity perspective, the tri-phase combination (T2WI + AP + VP) likely already captures the major imaging biomarkers of P53 mutation: T2-weighted imaging (T2WI) reflects tumor cellularity and water content, while the arterial phase captures characteristics of tumor neovascularization, and the portal venous phase demonstrates fibrotic features of the tumoral capsule [31–35], collectively containing most diagnostic information needed for P53 mutation detection, rendering HBP’s additional hepatobiliary metabolic data of limited incremental value.