In the PPI network, this gene interacts with another iDMC-containing gene GRM5 (metabotropic glutamate receptor 5, mGluR5), which has been well-studied in the context of PD and L-DOPA-induced dyskinesias, with inconsistent results in clinical trials targeting mGluR5 (Fig. 4A)50. Here, GRM5 is linked to drug-induced dyskinesia.