Although they display a pronounced capacity for tumor antigen uptake, promote the differentiation of CD4+ T cells into Th1, Th2, and Th17 phenotypes, and efficiently cross-present tumor antigens to CD8+ T cells, they express high levels of inducible nitric oxide synthase, leading to increased production of the T cell-suppressive molecule NO [20, 56]. This evidence concerns the gene CD8A and neoplasm.