MPPE1 and non-small cell lung carcinoma: Circulating DCs also differ between patients and healthy individuals: for instance, cDC2 are reduced in NSCLC and glioblastoma, increased in gastric cancer, while cDC1 decline in advanced melanoma [64–67].Furthermore, the relative proportions of DC subsets within tumors can change dynamically during tumor progression, and the total abundance of intratumoral DCs may also fluctuate, as demonstrated in the 3LL-R Lewis lung carcinoma model [20].