Meanwhile, untreated Zbp1−/− mice developed smaller tumors (9.65 ± 2.60 mm3) with moderate weight loss (-4.30 ± 9.99%) whereas CCL7-supplemented Zbp1−/− mice contained enlarged tumors (22.90 ± 11.65 mm3; p < 0.05) and experienced accelerated weight loss (-11.47 ± 9.53%;).Histopathological examination utilizing H&E staining demonstrated that BX471 effectively inhibited tumor progression in wild-type (WT) mice, as illustrated in Fig.7D-E. Here, ZBP1 is linked to neoplasm.