ZBP1 and colorectal neoplasm: Similarly, Karki et al. demonstrated that myeloid-specific ADAR1 deletion in Adar1fl/fl LysMcre mice upregulates ZBP1 expression, activating the RIPK3-mediated PANoptosome complex, a key driver of PANoptosis, to induce pyroptosis, necroptosis, and apoptosis, significantly suppressing colorectal tumor growth.