In a B-cell lymphoma model, NCG mice were intravenously inoculated with 1 × 106 NALM-6-luc cells on day 0, followed by infusion of 3 × 106 untransfected T cells, linear mRNA-, scarred cmRNA- or scarless cmRNA-based anti-CD19 CAR-T cells on day 3 (Fig. 7a). This evidence concerns the gene CD19 and B-cell non-Hodgkin lymphoma.