APC and colorectal cancer: For example, APC-mutated colorectal cancer showed higher ORR and prolonged TNT (hazard ratio, 0.82; 95% CI, 0.73-0.92; P < 0.001) for platinum-based drugs.<h4>Conclusions</h4>While genetic alterations alone did not outperform tumor origin as a predictor, incorporating both may improve exploratory predictions of chemotherapy response.