RIPK1 was positively correlated with the expression of cyclin E1 (CCNE1), CDK2, TIMP1, N-cadherin (CHD2), and other genes implicated in glioma proliferation and invasion [30–32], whereas MLKL exhibited a weaker or negative correlation with most genes in this signature (Fig. 2E). Here, TIMP1 is linked to central nervous system cancer.