Functionally, RIPK1 ablation suppresses GBM cell growth both in vitro and in vivo, leading to a significant downregulation of key cyclins (cyclin A2, B1, and E1) and arrest of the cell cycle at the S and G2/M phases (Figs. 2F–3G and 3B, C). Here, CCNA2 is linked to glioblastoma.