PIK3CA and non-small cell lung carcinoma: NSCLC activate the phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), signal transducer and activator of transcription 3 (STAT3) and WNT/β-catenin pathways, relying on astrocytic support and formation of an immune-suppressive metastatic niche6.