For example, the delivery of the transcription factors PU.1, IRF8, and BATF3 to cancer cells via replication-deficient adenovirus enables the direct reprogramming of cancer cells into dendritic cells.20 Compared with replication-deficient adenovirus vectors, OVs have the unique capability of selectively and directly delivering therapeutic payloads to cancer cells and increasing transgene copy number and expression efficiency via virus replication. This evidence concerns the gene IRF8 and cancer.