To further evaluate if genetic variation at the AQP3 gene locus is associated with islet expression, type 2 diabetes, or metabolic traits associated with blood glucose homeostasis (i.e., fasting blood glucose), we conducted genome wide association data look ups and analyzed islet specific expressions using RNA-seq data from human islets (n = 420) provided by the ISPIRE consortium. Here, AQP3 is linked to type 2 diabetes mellitus.